- Ed Hodgkin
- Prof. Stuart Forbes
Prof. John Campbell
- % Shareholding
- Number of employees
- Raised in a Series A financing in August 2020
Unless stated all data at 31 December 2020
Resolution is developing macrophage cell therapies to repair inflammatory organ damage.
Syncona co-founded Resolution following a two year collaboration with researchers at the University of Edinburgh and the Scottish National Blood Transfusion Service.
Resolution is developing macrophage cell therapies to repair inflammatory organ damage, including treatment of end-stage chronic liver disease. Macrophages are cells of the innate immune system which orchestrate the body’s defence against infection and injury; the company is built upon more than a decade of work in the Founders’ laboratories characterising the role of macrophages in organ repair, including the liver, both in the pre-clinical and clinical settings.
- An opportunity to create the leading inflammation-focused macrophage cell therapy business, focusing initially on treatment of liver cirrhosis. The goal is to repair the livers of patients sufficiently to reduce the risk of decompensation. Future opportunity lies in lung and kidney repair in chronic fibrotic disease.
Unmet medical need
- Chronic inflammatory organ damage represents a major burden to patients. If left untreated, liver cirrhosis will often progress to decompensation through significant loss of liver function. Today there are no efficacious treatments to prevent deterioration in the latter stages of the disease, thus leaving costly and burdensome liver transplantation often as the only option.
- New diagnoses of liver cirrhosis affect hundreds of individuals per million of population. Factoring in typical progression rates, tens of thousands of patients would be eligible each year for treatment with macrophage cell therapy in Western countries alone. The entire chronic inflammatory organ damage opportunity is even larger.
- Highly innovative concept in an emerging space
- Future competition