Clade Therapeutics

Series A
Chad Cowan
Chad Cowan
Jim Glasheen
Leandro Vetcher
Deepta Bhattacharya
Chris Sturgeon
Gustavo Mostoslavsky
% Shareholding
Number of employees
Raised in Series A

Unless stated all financials at 30 September 2023.

Clade website

Clade has been established with the aim of discovering and delivering scalable next generation induced pluripotent stem cell (iPSC)-derived medicines.

iPSCs are a type of pluripotent stem cell which can be generated directly from mature cells (such as those of the skin or blood). They hold great promise in the field of regenerative medicine, because they are able to multiply indefinitely, can be stored for long periods, and can produce tissue cells of any kind.

Clade’s work centres on its proprietary technology platform, which enables the immune “cloaking” of iPSCs. This means that when these cells are introduced to a patient, they are protected, or “cloaked”, from the individual’s own immune system. Potentially, this technology could allow for the creation of “off the shelf” treatments in donor derived cell therapies, which currently must engage with the challenge of introducing foreign cells to a patient without triggering a reaction from their own immune system. Clade is initially exploring the use of its iPSC technology in cancers, with a best-in-class approach to hypoimmunogenic engineering potentially allowing for a differentiated durability in response compared to other stem-cell based therapies.

The company is led by CEO Dr Chad Cowan, scientific co-founder of CRISPR Therapeutics and former Associate Professor at Harvard University in the Department of Stem Cell and Regenerative Biology, and Dr. Jim Glasheen, Chief Business Officer at Clade, co-founder of Atlanta Therapeutics and former general partner at Technology Partners Venture Capital. The company's leadership team have an unparalleled expertise in generating various different kinds of cells (including T, NK and B cells) from stem cells, helping to position Clade to be a leader in the iPSC space.

Investment thesis

  • Clade has been established with the aim of discovering and delivering scalable next generation induced pluripotent stem cell (iPSC)-derived medicines

Unmet medical need

  • Syncona believes Clade’s technology has the potential to deliver greater efficacy than the first generation of allogeneic cell therapies
  • “Off the shelf” stem cell-based therapies have potential to deliver practical and commercial benefits in cell therapeutics

Syncona team

Michael Kyriakides

Michael Kyriakides

Michael Kyriakides is an Investment Partner of Syncona Investment Management Ltd. He works closely with Syncona portfolio companies Freeline Therapeutics, Purespring Therapeutics, Beacon Therapeutics and Clade Therapeutics. He previously also supported Nightstar Therapeutics and Gyroscope Therapeutics. Prior to joining Syncona, Michael was a member of the Life Sciences team at L.E.K. Consulting an…
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Board observer
Raghd Rostom

Raghd Rostom

Raghd is an Associate Partner of Syncona Investment Management Ltd, and currently Head of Strategy and Operations at Kesmalea Therapeutics. Previously, Raghd was a core member of the healthcare practice at the Boston Consulting Group, with a particular focus on strategy and digital areas across Pharma, Biotech and Global Health sectors. Prior to BCG, Raghd completed a multidisciplinary PhD at the…
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Clade Therapeutics leaders and founders

Chad Cowan

Chad Cowan

Chief Executive Officer and Co-Founder
Jim Glasheen

Jim Glasheen

President / Chief Business Officer and Co-Founder
Leandro Vetcher

Leandro Vetcher

Chief Operating Officer and Co-Founder

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