Freeline announces acceptance of Late Breaking Abstract at the International Society on Thrombosis and Haemostasis (ISTH) 2020 Meeting

Freeline, a biotechnology company focused on developing curative gene therapies for chronic systemic diseases, today announces that Professor Pratima Chowdary of the Katharine Dormandy Haemophilia and Thrombosis Centre, Royal Free Hospital UK and UCL Cancer Institute, and Chief investigator for the study, will present data in a late-breaking abstract session at the International Society on Thrombosis and Haemostasis (ISTH) 2020 Congress on behalf of co-authors, which will be held virtually 12-14 July 2020. In addition, Freeline has five posters at the conference and will be presenting data on the Factor IX Padua variant and health economics from its Adeno-Associated Virus (AAV)-based haemophilia gene therapy platform.

“We are pleased to have an abstract on our novel investigational gene therapy treatment for haemophilia B accepted as a late-breaking abstract at the upcoming ISTH conference,” said Theresa Heggie, CEO. “Results we have presented previously from our lead program suggest that FLT180a has the potential to create sustained FIX activity levels in the normal range in patients with severe haemophilia B and has the potential to address a significant unmet medical need and advance the standard of care.” 

Late breaking abstract:

Title: A novel adeno associated virus (AAV) gene therapy (FLT180a) achieves normal FIX activity levels in severe Hemophilia B (HB) patients (B-AMAZE study)

Presenter: Prof. Pratima Chowdary

Session: Late Breaking and CPVOD-19 Oral Communication Session

Date & Time: Monday, July 13, 2020 at 11.45 AM – 13.00 PM ET

Additional five abstracts/poster presentations:

Title: Multi-centre field study of one-stage and chromogenic Factor IX assays in samples containing the Factor IX Padua variant

Abstract No: A-1120-0035-00542

Title: Mechanistic evaluation of Factor IX-Padua activity in chromogenic FIX and thrombin generation assays

Abstract No: A-1120-0035-00721

Title: Feasibility of Using Hospital Episode Statistics in England to Assess the Resource Use and Outcomes in Haemophilia

Abstract No: A-1120-0033-02562

Title: The Relationship between Societal Costs Associated with Haemophilia and Disease Severity: A Regression Analysis Using CHESS II Data

Abstract No: A-1120-0033-02935

Title: Modelling the Cost of Equivalent trough Level across Gene Therapy and Factor IX Replacement Therapy in Haemophilia B

Abstract No:  A-1120-0033-02961

Founded in 1969, the ISTH is the leading worldwide not-for-profit organization dedicated to advancing the understanding, prevention, diagnosis and treatment of thrombotic and bleeding disorders. ISTH is an international professional membership organisation with more than 5,000 clinicians, researchers and educators working together to improve the lives of patients in more than 100 countries around the world.

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