A portfolio of life science companies diversified across a range of therapeutic areas and different stages of the development cycle.
Portfolio in numbers*
Value of life sciences portfolio
High quality companies
Clinical trials in portfolio
10-year targets
Portfolio of leading life science companies
New companies founded per year
Companies to the point of product approval
A differentiated and diversified portfolio
To deliver sustainable value we seek to build a portfolio of 20-25 companies, with each company built on a product-focused strategy. Over portfolio is diversified across therapeutic areas and different stages of the development cycle.
*Unless stated all financials at 31 December 2022
Cell therapy is the introduction of selected, and sometimes engineered, cells into a patient, harnessing the power of a patient’s immune system to combat their disease. The therapy may have wide applications as a cancer treatment, with the potential for cure in some patients.
Autolus
Autolus is a clinical-stage biopharmaceutical company focusing on the development of precisely targeted, controlled and highly active T effector cell therapies that are designed to offer cancer patients substantial benefits over existing standard of care.
- Cell type
- CAR-T
- Stage
- Clinical
Unless stated all data at 30 September 2022
Achilles Therapeutics
Achilles Therapeutics is a clinical-stage biopharmaceutical company developing novel cancer immunotherapies targeting clonal neoantigens: protein markers unique to each individual that are expressed on the surface of every cancer cell.
- Cell type
- TILs
- Stage
- Clinical
All data at 30 September 2022
Quell Therapeutics
Quell Therapeutics was founded with the aim of developing engineered T regulatory (Treg) cell therapies. Tregs are a subset of T cells with the potential to downregulate the immune system.
- Cell type
- T-Reg
- Stage
- Pre-clinical
Unless stated all data at 30 September 2022
Resolution Therapeutics
Resolution is developing macrophage cell therapies to repair inflammatory organ damage.
- Cell type
- Macrophage
- Stage
- Pre-clinical
Unless stated all data at 30 September 2021
Clade Therapeutics
Clade has been established with the aim of discovering and delivering scalable next generation induced pluripotent stem cell (iPSC)-derived medicines.
- Stage
- Pre-Clinical
Unless stated all financials at 30 September 2021
Gene therapy is the introduction of genetic material into cells to replace missing or defective genes. If a gene doesn’t function properly, the introduction of a normal copy of a gene may be able to treat or prevent disease. It is a technique that has the potential to deliver long-term and potentially curative benefits to patients with genetic disorders.
Freeline Therapeutics
Freeline is a clinical-stage biotechnology company developing transformative gene therapies for patients suffering from inherited systemic debilitating diseases.
- Target tissue compartment
- Systemic
- Stage
- Clinical
Unless stated all data at 30 September 2021
AGTC
Applied Genetic Technologies Corporation (AGTC) is a clinical-stage company focused on the development and commercialisation of adeno-associated virus (AAV)-based gene therapies for the treatment of rare and debilitating diseases with an initial focus on inherited retinal diseases. Syncona completed its acquisition of AGTC in November 2022 for an initial investment of $23.3 million.
SwanBio Therapeutics
SwanBio Therapeutics is a gene therapy company developing leading-edge medicines to deliver dramatic clinical efficacy for the treatment of genetically defined neurological conditions.
- Target tissue compartment
- CNS
- Stage
- Pre-clinical
All data at 31 December 2020
Purespring Therapeutics
Purespring seeks to advance gene therapies for the treatment of chronic renal diseases that are currently poorly addressed with existing treatments.
- Target tissue compartment
- Renal
- Stage
- Pre-clinical
All data at 31 December 2020
Anaveon
Anaveon is a clinical phase biopharmaceutical company that specialises in the development of treatments for diseases with immune system dysfunction.
- Focus
- Immune system dysfunction
- Stage
- Pre-clinical
Unless stated all data at 31 December 2020
A small molecule is a small, chemically manufactured compound with a low molecular weight. Small molecule drugs help regulate a biological target such as an enzyme, channel or receptor to modify a disease process.
OMass Therapeutics
OMass Therapeutics is an Oxford University spin-out backed by Syncona and Oxford Science Enterprises that is using novel biochemistry techniques, native mass spectrometry and custom chemistry to deliver novel medicines against highly validated but inadequately drugged targets, with a focus on immunological and rare diseases.
- Focus
- Native Mass Spectrometry
- Stage
- Drug discovery
Kesmalea Therapeutics
Kesmalea is a small molecule drug discovery company established with the aim of creating a new generation of oral drugs addressing diseases through modulating protein homeostasis. Syncona led a £20 million Series A financing in the company in 2022, committing £16 million alongside Oxford Science Enterprises.
- Focus
- Protein homeostasis
- Stage
- Drug discovery
Mosaic Therapeutics
Based in Cambridge, UK, Mosaic is an oncology therapeutics company with a highly specialised drug discovery platform, focused on discovering, developing and commercialising novel, targeted, therapies to target cancers in areas of high unmet need. Syncona led a £22.5 million Series A financing of the company in 2022, committing £16 million alongside Cambridge Innovation Capital.
As we seek to build a diversified portfolio of 15-20 companies, some companies may not succeed and we may receive attractive offers for our companies from third parties.
Gyroscope Therapeutics
Syncona founded Gyroscope in 2016, to explore the convergence of advancements made in the understanding of the complement system’s impact on eye disease, the genetic basis of dry age-related macular degeneration (AMD), and gene therapy as a mode of sustained treatment delivery. Gyroscope’s gene therapy seeks to treat dry AMD by safely and effectively delivering a functioning gene to the eye using Adeno-Associated Virus (AAV) technology.
Blue Earth
Blue Earth Diagnostics was founded to develop and commercialise molecular imaging agents, addressing areas of high unmet medical need.
Nightstar
Nightstar was a leading clinical-stage gene therapy company focused on developing and commercialising novel one-time treatments for patients suffering from rare inherited retinal diseases that would otherwise progress to blindness.
Neogene Therapeutics
Neogene was founded in 2018, based on the work of Dr Ton Schumacher, a leading cancer immunologist, and Dr Carsten Linnemann, who was previously associate director of next generation T cell therapy at Kite Pharma. In 2020 Syncona co-led the company’s $110 million Series A financing round, committing $19 million alongside EcoR1 Capital, Jeito Capital, Polaris Partners, Pontifax, Vida Ventures, TPG and Two River.
14MG
14M Genomics was a cancer diagnostic business that was founded in partnership with the Wellcome Trust Sanger Institute in 2014.
Azeria Therapeutics
Azeria was a small molecule drug discovery company targeting treatment of oestrogen receptor positive breast cancer.
Attracting world-class talent within our portfolio
Introduction to Richard Francis, Chief Executive of Purespring Therapeutics
