Dr Marc Martinez-Llordella
Marc serves as Vice President Biology and has forged a deep academic research career focused on Tregs biology and immunological tolerance. His most recent research as Senior Lecturer at King’s College London has combined pre-clinical models and deep phenotyping of clinical samples to identify new strategies to modulate Treg homeostasis and function. Marc’s group has investigated the role of microenviromental cues such as IL-2 availability and inflammation shaping the phenotypic characteristics of tissue resident T cells. His translational research has supported the implementation of new tolerogenic therapies such as low-dose IL-2 and CAR-Tregs into transplantation and autoimmunity. From a clinical aspect, Marc has led the immunomonitoring analysis of several trials associated on liver transplantation tolerance. Prior to that he worked in Professor Jeff Bluestones lab at University College San Francisco where he carried out post-doctoral research on the transcriptional profile of CD28 signalling in T cell activation and the analysis of Treg phenotypic plasticity in autoimmunity. Marc holds a PhD from the University of Barcelona focussed on the identification of transcriptional and phenotypic biomarkers to predict transplantation tolerance.